Spirulina Algae, Spirulina

Spirulina is a type of blue-green seaweed known as a very good plant based source of protein, iron and vitamin B12. It promotes a lot of different benefits to the human body, like improving glucose and lipid metabolism, preventing oxidation, promoting cardiovascular health and reducing liver fat.

  • Origin: Plant Based
  • Source: Itself
  • Type: Herbs, Roots & Barks
  • Age Range: Adults, Seniors
  • Toxicity: There is no evidence of toxicity until now
  • Outcomes: Specific Conditions, Respiratory Allergies, Blood Pressure, Cholesterol and Triglycerides, Blood Sugar Control

What are Spirulina benefits?

Spirulina is a type of non-toxic blue-green algae (cyanobacteria), considered a superfood by people because of its high nutritional content and health benefits. The use of spirulina is generally associated with a vegan source of protein and iron, in addition to other nutrients and phytochemicals. It is also worth noting that the main ingredient is phycocyanobilin, which makes up about 1% of spirulina. This ingredient mimics the body’s bilirubin compound in order to inhibit an enzyme complex called nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. By inhibiting NADPH oxidase, spirulina provides potent antioxidant and anti-inflammatory effects. And among the main benefits of spirulina, according to scientific evidence, are: general improvement in the basic components of the lipid panel, such as triglycerides, HDL, LDL, VLDL, and total cholesterol, reduction of blood pressure by a small amount, and loss of a small amount of weight, among others. Some studies that still need further research have also indicated that spirulina helps with liver enzymes and overall liver health, appetite regulation, prevention of allergic reactions and asthma treatment, and improved athletic performance.

Table of relations

Outcome
Sub-Outcome
Consistent effects
Strength of effects
Scientific articles

Specific Conditions Spirulina and Specific Conditions

Specific body conditions categorize precise areas of our body, such as: Respiratory allergies; Liver; Eye health; Blood pressure; Cholesterol and triglycerides; and Blood glucose control. These areas require specific attention because they are delicate functions related to other parts of the body. Respiratory allergies, for example, are linked to the immune system, and to present an effective nutraceutical, we keep our scientific base up to date.
  • Respiratory Allergies

    Respiratory allergies are directly linked to the immune system. Like a defender, our immunity responds to infectious agents by provoking some reaction, likewise an allergy is the immune system's overreaction to certain substances, such as dust, pollen, animal hair, and others. These allergies can be very uncomfortable and are common in people who are genetically predisposed or who are more sensitive to certain elements. Treating the symptoms of these allergies can prevent uncomfortable moments, as well as making it possible to be in places or with animals that previously would not have been possible.

  • Blood Pressure

    Blood pressure is the pressure of circulating blood against the walls of blood vessels which results from the heart pumping blood through the circulatory system. Like most aspects of the organism, this too needs to stay at a healthy range, for the circulation of oxygen and nutrients throughout the body.

  • Cholesterol and Triglycerides

    Triglycerides and cholesterol are both types of fat present in blood. They play very important roles in the body, such as hormone metabolism and nutrient circulation. In order for them to function properly, they need to be at optimum levels - not too high neither too low. The primary way to keep those good levels is to have a healthy diet, with lots of fiber and balanced fats. But there are some nutraceutics that have been proven to help in this process in a very effective way.

  • Blood Sugar Control

    The body's cells use glucose to produce energy. Glucose comes from food and is stored in the body in the form of glycogen (in the muscles and liver) or circulating glucose (in the blood). Cells need the hormone Insulin to capture glucose molecules. The glucose / insulin balance in the blood is essential for the proper functioning of the body's whole metabolism. A change in this metabolism can lead to serious physiological dysfunctions, leading to the development of chronic non-communicable diseases, such as type II diabetes and cardiovascular diseases. There are several classes of compounds that influence this metabolism, these can increase insulin synthesis and secretion, decrease blood glucose levels, reduce the immediate absorption of carbohydrates, regulate the sensitivity of cells to insulin, among others.

Related videos about Spirulina

References

  1. a b c d e f Marles RJ, et al. United States pharmacopeia safety evaluation of spirulinaCrit Rev Food Sci Nutr. (2011)
  2. a b c d Ciferri O. Spirulina, the edible microorganismMicrobiol Rev. (1983)
  3. a b c d Habib MA, et al. A review on culture, production and use of spirulina as food for humans and feeds for domestic animals and fishFAO Fisheries and Aquaculture Circular. (2008)
  4. ^ Kebede E, Ahlgren G. Optimum growth conditions and light utilization efficiency of Spirulina platensis (= Arthrospira fusiformis) (Cyanophyta) from Lake Chitu, EthiopiaHydrobiologia. (1996)
  5. ^ Liu Q, et al. Medical Application of Spirulina platensis Derived C-PhycocyaninEvid Based Complement Alternat Med. (2016)
  6. a b c d McCarty MF. Clinical potential of Spirulina as a source of phycocyanobilinJ Med Food. (2007)
  7. ^ Chaiklahan R, et al. Separation and purification of phycocyanin from Spirulina sp. using a membrane processBioresour Technol. (2011)
  8. a b McCarty MF, Barroso-Aranda J, Contreras F. Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disordersMed Hypotheses. (2010)
  9. a b Pugh N, et al. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosaPlanta Med. (2001)
  10. ^ Colla LM, Bertolin TE, Costa JA. Fatty acids profile of Spirulina platensis grown under different temperatures and nitrogen concentrationsZ Naturforsch C. (2004)
  11. ^ Li ZY, et al. Effects of electromagnetic field on the batch cultivation and nutritional composition of Spirulina platensis in an air-lift photobioreactorBioresour Technol. (2007)
  12. ^ Watanabe F, et al. Characterization and bioavailability of vitamin B12-compounds from edible algaeJ Nutr Sci Vitaminol (Tokyo). (2002)
  13. ^ Watanabe F, et al. Pseudovitamin B(12) is the predominant cobamide of an algal health food, spirulina tabletsJ Agric Food Chem. (1999)
  14. ^ Park WS, et al. Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant ActivitiesMolecules. (2018)
  15. ^ Soudy ID, et al. Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake areaPLoS One. (2018)
  16. ^ Wang J, et al. Vitamin A equivalence of spinach beta-carotene in human bodyWei Sheng Yan Jiu. (2007)
  17. ^ Yu B, et al. Spirulina is an effective dietary source of zeaxanthin to humansBr J Nutr. (2012)
  18. ^ Hinds TD Jr, Stec DE. Bilirubin, a Cardiometabolic Signaling MoleculeHypertension. (2018)
  19. ^ Panday A, et al. NADPH oxidases: an overview from structure to innate immunity-associated pathologiesCell Mol Immunol. (2015)
  20. ^ Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyPhysiol Rev. (2007)
  21. a b McCarty MF, Barroso-Aranda J, Contreras F. NADPH oxidase mediates glucolipotoxicity-induced beta cell dysfunction–clinical implicationsMed Hypotheses. (2010)
  22. ^ Olsson R, Stigendal L. Clinical experience with isolated hyperbilirubinemiaScand J Gastroenterol. (1989)
  23. ^ Kulkarni RG, et al. Gilbert’s syndrome in healthy blood donors what next??Asian J Transfus Sci. (2016)
  24. ^ Horsfall LJ, et al. Gilbert’s syndrome and the risk of death: a population-based cohort studyJ Gastroenterol Hepatol. (2013)
  25. ^ Maruhashi T, et al. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndromeCirculation. (2012)
  26. ^ Kundur AR, Singh I, Bulmer AC. Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert’s syndrome?Atherosclerosis. (2015)
  27. ^ Goel A, Aggarwal R. Unconjugated hyperbilirubinemia: a blessing in disguise?J Gastroenterol Hepatol. (2013)
  28. ^ McCarty MF. ”Iatrogenic Gilbert syndrome”–a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubinMed Hypotheses. (2007)
  29. ^ DiNicolantonio JJ, McCarty MF, O’Keefe JH. Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complicationsOpen Heart. (2018)
  30. ^ Altenhöfer S, et al. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target EngagementAntioxid Redox Signal. (2015)
  31. ^ Salazar M, et al. Subchronic toxicity study in mice fed Spirulina maximaJ Ethnopharmacol. (1998)
  32. ^ Yang Y, et al. In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensisFood Chem Toxicol. (2011)
  33. a b c d Jensen GS, et al. Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet ActivationJ Med Food. (2016)
  34. ^ Petrus M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergenAllergy. (2010)
  35. ^ Dietrich D, Hoeger S. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach?Toxicol Appl Pharmacol. (2005)
  36. ^ Gilroy DJ, et al. Assessing potential health risks from microcystin toxins in blue-green algae dietary supplementsEnviron Health Perspect. (2000)
  37. ^ Roy-Lachapelle A, et al. Detection of Cyanotoxins in Algae Dietary SupplementsToxins (Basel). (2017)
  38. ^ Marsan DW, et al. Evaluation of microcystin contamination in blue-green algal dietary supplements using a protein phosphatase inhibition-based test kitHeliyon. (2018)
  39. ^ Heussner AH, et al. Toxin content and cytotoxicity of algal dietary supplementsToxicol Appl Pharmacol. (2012)
  40. ^ Vichi S, et al. Contamination by Microcystis and microcystins of blue-green algae food supplements (BGAS) on the Italian market and possible risk for the exposed populationFood Chem Toxicol. (2012)
  41. ^ Al-Dhabi NA. Heavy metal analysis in commercial Spirulina products for human consumptionSaudi J Biol Sci. (2013)
  42. a b Muys M, et al. High variability in nutritional value and safety of commercially available Chlorella and Spirulina biomass indicates the need for smart production strategiesBioresour Technol. (2018)
  43. ^ Doshi H, Ray A, Kothari IL. Biosorption of cadmium by live and dead Spirulina: IR spectroscopic, kinetics, and SEM studiesCurr Microbiol. (2007)
  44. ^ Solisio C, et al. Cadmium biosorption on Spirulina platensis biomassBioresour Technol. (2008)
  45. ^ Cain A, Vannela R, Woo LK. Cyanobacteria as a biosorbent for mercuric ionBioresour Technol. (2008)
  46. ^ Fang L, et al. Binding characteristics of copper and cadmium by cyanobacterium Spirulina platensisJ Hazard Mater. (2011)
  47. a b Saha SK, Misbahuddin M, Ahmed AU. Comparison between the effects of alcohol and hexane extract of spirulina in arsenic removal from isolated tissuesMymensingh Med J. (2010)
  48. a b Saha SK, et al. Effect of hexane extract of spirulina in the removal of arsenic from isolated liver tissues of ratMymensingh Med J. (2005)
  49. ^ Banji D, et al. Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluorideFood Chem. (2013)
  50. a b Gargouri M, et al. Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn ratsFood Chem Toxicol. (2012)
  51. ^ Paniagua-Castro N, et al. Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in miceJ Med Food. (2011)
  52. a b c d El-Desoky GE, et al. Improvement of Mercuric Chloride-Induced Testis Injuries and Sperm Quality Deteriorations by Spirulina platensis in RatsPLoS One. (2013)
  53. ^ Sharma MK, et al. Evaluation of protective efficacy of Spirulina fusiformis against mercury induced nephrotoxicity in Swiss albino miceFood Chem Toxicol. (2007)
  54. ^ Madhyastha HK, et al. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cellsPhytomedicine. (2006)
  55. ^ Saxena PS, Kumar M. Modulatory potential of Spirulina fusiformis on testicular phosphatases in Swiss albino mice against mercury intoxicationIndian J Exp Biol. (2004)
  56. ^ Sharma MK, et al. Modification of mercury-induced biochemical alterations in blood of Swiss albino mice by Spirulina fusiformisEnviron Toxicol Pharmacol. (2005)
  57. ^ Simsek N, et al. Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in ratsJ Hazard Mater. (2009)
  58. ^ Karadeniz A, Cemek M, Simsek N. The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in ratsEcotoxicol Environ Saf. (2009)
  59. a b Jeyaprakash K, Chinnaswamy P. Effect of spirulina and Liv-52 on cadmium induced toxicity in albino ratsIndian J Exp Biol. (2005)
  60. a b Jeyaprakash K, Chinnaswamy P. Hypocholesterolaemic effect of spirulina and liv-52 in lead induced toxicity in albino ratsAnc Sci Life. (2004)
  61. a b Misbahuddin M, et al. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled studyClin Toxicol (Phila). (2006)
  62. a b c Savranoglub S, Tumer TB. Inhibitory Effects of Spirulina platensis on Carcinogen-Activating Cytochrome P450 Isozymes and Potential for Drug InteractionsInt J Toxicol. (2013)
  63. a b c Nishanth RP, et al. C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell lineEur J Pharmacol. (2010)
  64. ^ Roy KR, et al. C-Phycocyanin ameliorates 2-acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino miceHepatol Res. (2008)
  65. ^ Roy KR, et al. C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysisArch Biochem Biophys. (2007)
  66. ^ Khan M, et al. C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytesJ Cardiovasc Pharmacol. (2006)
  67. ^ Terry MJ, Maines MD, Lagarias JC. Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductaseJ Biol Chem. (1993)
  68. ^ Riss J, et al. Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamstersJ Agric Food Chem. (2007)
  69. a b c d e Pabon MM, et al. A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson’s DiseasePLoS One. (2012)
  70. ^ Cardona AE, et al. Control of microglial neurotoxicity by the fractalkine receptorNat Neurosci. (2006)
  71. a b CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson’s disease.
  72. ^ Rimbau V, et al. Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampusNeurosci Lett. (1999)
  73. ^ Patel M, et al. Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damageJ Neurochem. (2005)
  74. ^ Lanone S, et al. Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in ratsFASEB J. (2005)
  75. ^ Chamorro G, et al. Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicityNutr Neurosci. (2006)
  76. ^ Strömberg I, et al. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine systemExp Neurol. (2005)
  77. ^ Wu DC, et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson’s diseaseProc Natl Acad Sci U S A. (2003)
  78. ^ Tieu K, Ischiropoulos H, Przedborski S. Nitric oxide and reactive oxygen species in Parkinson’s diseaseIUBMB Life. (2003)
  79. ^ Zhang W, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson’s disease model: role of NADPH oxidaseFASEB J. (2004)
  80. ^ Choi DH, et al. NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson’s diseaseAntioxid Redox Signal. (2012)
  81. ^ Thaakur SR, Jyothi B. Effect of spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in ratsJ Neural Transm. (2007)
  82. ^ Subramanyam B, et al. Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in ratsBiochem Biophys Res Commun. (1990)
  83. ^ Eyles DW, McGrath JJ, Pond SM. Formation of pyridinium species of haloperidol in human liver and brainPsychopharmacology (Berl). (1996)
  84. ^ Thaakur S, Sravanthi R. Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in ratsJ Neural Transm. (2010)
  85. ^ Wang Y, et al. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damageExp Neurol. (2005)
  86. ^ Pentón-Rol G, et al. C-Phycocyanin is neuroprotective against global cerebral ischemia/reperfusion injury in gerbilsBrain Res Bull. (2011)
  87. a b Bermejo-Bescós P, Piñero-Estrada E, Villar del Fresno AM. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cellsToxicol In Vitro. (2008)
  88. ^ George S, et al. α-Synuclein: The Long Distance RunnerBrain Pathol. (2013)
  89. ^ Lehéricy S, et al. Magnetic resonance imaging of the substantia nigra in Parkinson’s diseaseMov Disord. (2012)
  90. ^ Surmeier DJ, et al. The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson’s diseaseNeuroscience. (2011)
  91. a b Guo JP, Yu S, McGeer PL. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer’s disease therapyJ Alzheimers Dis. (2010)
  92. a b Hwang JH, et al. Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated miceJ Nutr Sci Vitaminol (Tokyo). (2011)
  93. ^ Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.
  94. ^ Zhang QG, et al. Critical role of NADPH oxidase in neuronal oxidative damage and microglia activation following traumatic brain injuryPLoS One. (2012)
  95. ^ Chen JC, et al. Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cellsNutr Neurosci. (2012)
  96. a b c Patro N, et al. Spirulina platensis protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic ratsIndian J Exp Biol. (2011)
  97. ^ Gemma C, et al. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokinesJ Neurosci. (2002)
  98. a b c d Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Proliferation.
  99. ^ Short Communication: Neuroprotective Effect of Spirulina in a Mouse Model of ALS.
  100. ^ ALSUntangled Group. ALSUntangled No. 9: Blue-green algae (Spirulina) as a treatment for ALSAmyotroph Lateral Scler. (2011)
  101. a b Kim NH, et al. The effect of hydrolyzed Spirulina by malted barley on forced swimming test in ICR miceInt J Neurosci. (2008)
  102. a b c d Huang H, et al. Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressureDiabetes Metab Syndr Obes. (2018)
  103. ^ Carrizzo A, et al. Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent MechanismHypertension. (2019)
  104. ^ Juárez-Oropeza MA, et al. Effects of dietary Spirulina on vascular reactivityJ Med Food. (2009)
  105. ^ Brito AF, et al. Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and AntioxidantsFront Physiol. (2018)
  106. ^ Hsiao G, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensisJ Agric Food Chem. (2005)
  107. a b Torres-Durán PV, et al. Effect of Spirulina maxima on postprandial lipemia in young runners: a preliminary reportJ Med Food. (2012)
  108. ^ Nagaoka S, et al. A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in ratsJ Nutr. (2005)
  109. ^ Serban MC, et al. A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrationsClin Nutr. (2016)
  110. ^ Szulinska M, et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled studyEur Rev Med Pharmacol Sci. (2017)
  111. a b Marcel AK, et al. The effect of Spirulina platensis versus soybean on insulin resistance in HIV-infected patients: a randomized pilot studyNutrients. (2011)
  112. ^ Vigouroux C, et al. Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV diseaseDiabetes Metab. (1999)
  113. ^ Parikh P, Mani U, Iyer U. Role of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes MellitusJ Med Food. (2001)
  114. ^ Kaur K, Sachdeva R, Grover K. Effect of supplementation of spirulina on blood glucose and lipid profile of the non-insulin dependent diabetic male subjectsAsian Journal of Dairy and Food Research. (2008)
  115. ^ Lee EH, et al. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patientsNutr Res Pract. (2008)
  116. a b c d e Fujimoto M, et al. Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndromeDig Liver Dis. (2012)
  117. ^ Obesity is associated with macrophage accumulation in adipose tissue.
  118. a b Furukawa S, et al. Increased oxidative stress in obesity and its impact on metabolic syndromeJ Clin Invest. (2004)
  119. ^ Iwatsuka H, Shino A, Suzuoki Z. General survey of diabetic features of yellow KK miceEndocrinol Jpn. (1970)
  120. ^ Ou Y, et al. Antidiabetic potential of phycocyanin: Effects on KKAy micePharm Biol. (2013)
  121. a b c d Nielsen CH, et al. Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteinsPlanta Med. (2010)
  122. ^ Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components.
  123. ^ Balachandran P, et al. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in miceInt Immunopharmacol. (2006)
  124. ^ Ku CS, et al. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytesBiochim Biophys Acta. (2013)
  125. ^ SCN Signs Major World-Wide Distribution Agreement for Patented Immune Product.
  126. ^ Grzanna R, et al. Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cellsJ Altern Complement Med. (2006)
  127. a b DuBois RN, et al. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumorsGastroenterology. (1996)
  128. a b c d Saini MK, Sanyal SN. PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in ratExp Mol Pathol. (2012)
  129. ^ Reddy MC, et al. C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophagesBiochem Biophys Res Commun. (2003)
  130. a b c d Reddy CM, et al. Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensisBiochem Biophys Res Commun. (2000)
  131. ^ Shih CM, et al. Antiinflammatory and antihyperalgesic activity of C-phycocyaninAnesth Analg. (2009)
  132. ^ Nemoto-Kawamura C, et al. Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticlesJ Nutr Sci Vitaminol (Tokyo). (2004)
  133. a b Hirahashi T, et al. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensisInt Immunopharmacol. (2002)
  134. a b c d e Akao Y, et al. Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in miceCancer Sci. (2009)
  135. ^ Akazawa T, et al. Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cellsProc Natl Acad Sci U S A. (2007)
  136. a b c Pak W, et al. Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitisJ Clin Biochem Nutr. (2012)
  137. a b Joventino IP, et al. The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic ratsJ Complement Integr Med. (2012)
  138. a b Kumar N, et al. Evaluation of protective efficacy of Spirulina platensis against collagen-induced arthritis in ratsInflammopharmacology. (2009)
  139. a b Rasool M, Sabina EP, Lavanya B. Anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in miceBiol Pharm Bull. (2006)
  140. a b Remirez D, et al. Inhibitory effects of Spirulina in zymosan-induced arthritis in miceMediators Inflamm. (2002)
  141. a b Cingi C, et al. The effects of spirulina on allergic rhinitisEur Arch Otorhinolaryngol. (2008)
  142. ^ Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patientsJ Med Food. (2005)
  143. a b Park HJ, et al. A randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly KoreansAnn Nutr Metab. (2008)
  144. a b Chu WL, et al. Protective effect of aqueous extract from Spirulina platensis against cell death induced by free radicalsBMC Complement Altern Med. (2010)
  145. a b Shyam R, et al. Wheat grass supplementation decreases oxidative stress in healthy subjects: a comparative study with spirulinaJ Altern Complement Med. (2007)
  146. a b Chamorro-Cevallos G, et al. Chemoprotective effect of Spirulina (Arthrospira) against cyclophosphamide-induced mutagenicity in miceFood Chem Toxicol. (2008)
  147. a b c Hassan AM, Abdel-Aziem SH, Abdel-Wahhab MA. Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and Whey protein concentrateEcotoxicol Environ Saf. (2012)
  148. ^ Deryagina VP, Ryzhova NI, Golubkina NA. Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumorsExp Oncol. (2012)
  149. ^ Mathew B, et al. Evaluation of chemoprevention of oral cancer with Spirulina fusiformisNutr Cancer. (1995)
  150. ^ Mishima T, et al. Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensisClin Exp Metastasis. (1998)
  151. ^ McCarty MF. Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer preventionMed Hypotheses. (2012)
  152. a b Saini MK, Sanyal SN, Vaiphei K. Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathwayNutr Cancer. (2012)
  153. a b c Saini MK, Vaiphei K, Sanyal SN. Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyaninMol Cell Biochem. (2012)
  154. a b Voltarelli FA, de Mello MA. Spirulina enhanced the skeletal muscle protein in growing ratsEur J Nutr. (2008)
  155. ^ Efficacy of Spirulina Supplementation on Isometric Strength and Isometric Endurance of Quadriceps in Trained and Untrained Individuals – a comparative study.
  156. a b c Lu HK, et al. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stressEur J Appl Physiol. (2006)
  157. ^ Kalafati M, et al. Ergogenic and antioxidant effects of spirulina supplementation in humansMed Sci Sports Exerc. (2010)
  158. ^ Baicus C, Baicus A. Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trialsPhytother Res. (2007)
  159. ^ Ishimi Y, et al. Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded miceBiosci Biotechnol Biochem. (2006)
  160. a b Bhattacharyya S, Mehta P. The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicityFood Funct. (2012)
  161. ^ Lu J, et al. Protection by dietary Spirulina platensis against D-galactosamine–and acetaminophen-induced liver injuriesBr J Nutr. (2010)
  162. a b Jarouliya U, et al. Alleviation of metabolic abnormalities induced by excessive fructose administration in Wistar rats by Spirulina maximaIndian J Med Res. (2012)
  163. ^ Effect of Supplementation of Spirulina on Hypercholesterolemic Patients.
  164. ^ McCarty MF, Barroso-Aranda J, Contreras F. Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cellsMed Hypotheses. (2009)
  165. ^ Liu XJ, et al. Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cellsWorld J Gastroenterol. (2002)
  166. ^ Itagaki T, et al. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cellsGut. (2005)
  167. ^ Bataller R, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosisJ Clin Invest. (2003)
  168. ^ Adachi T, et al. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cellsHepatology. (2005)
  169. ^ Nakanishi Y, et al. Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasiaJ Autoimmun. (2008)
  170. ^ Moura LP, et al. Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar ratsLipids Health Dis. (2011)
  171. ^ Blé-Castillo JL, et al. Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to miceLife Sci. (2002)
  172. a b Ferreira-Hermosillo A, Torres-Duran PV, Juarez-Oropeza MA. Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case seriesJ Med Case Rep. (2010)
  173. ^ Hernández-Corona A, et al. Antiviral activity of Spirulina maxima against herpes simplex virus type 2Antiviral Res. (2002)
  174. a b Yakoot M, Salem A. Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trialBMC Gastroenterol. (2012)
  175. ^ Băicuş C, Tănăsescu C. Chronic viral hepatitis, the treatment with spiruline for one month has no effect on the aminotransferasesRom J Intern Med. (2002)
  176. ^ Teas J, Irhimeh MR. Dietary algae and HIV/AIDS: proof of concept clinical dataJ Appl Phycol. (2012)
  177. a b Selmi C, et al. The effects of Spirulina on anemia and immune function in senior citizensCell Mol Immunol. (2011)
  178. a b Gupta M, Dwivedi UN, Khandelwal S. C-Phycocyanin: an effective protective agent against thymic atrophy by tributyltinToxicol Lett. (2011)
  179. ^ Rodríguez-Sánchez R, et al. Phycobiliproteins or C-phycocyanin of Arthrospira (Spirulina) maxima protect against HgCl(2)-caused oxidative stress and renal damageFood Chem. (2012)
  180. ^ Mohan IK, et al. Protection against cisplatin-induced nephrotoxicity by Spirulina in ratsCancer Chemother Pharmacol. (2006)
  181. ^ Lim BJ, et al. C-phycocyanin attenuates cisplatin-induced nephrotoxicity in miceRen Fail. (2012)
  182. ^ Sinanoglu O, et al. The Protective Effects of Spirulina in Cyclophosphamide Induced Nephrotoxicity and Urotoxicity in RatsUrology. (2012)
  183. ^ Viswanadha VP, Sivan S, Rajendra Shenoi R. Protective effect of Spirulina against 4-nitroquinoline-1-oxide induced toxicityMol Biol Rep. (2011)
  184. ^ Avdagić N, et al. Spirulina platensis protects against renal injury in rats with gentamicin-induced acute tubular necrosisBosn J Basic Med Sci. (2008)
  185. ^ Kim DH, et al. Molecular Study of Dietary Heptadecane for the Anti-Inflammatory Modulation of NF-kB in the Aged KidneyPLoS One. (2013)
  186. ^ Sun YX, et al. Experimental study on the therapeutic effect of C-phycocyanin against pulmonary fibrosis induced by paraquat in ratsZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. (2012)
  187. a b c Bickford PC, et al. Nutraceuticals synergistically promote proliferation of human stem cellsStem Cells Dev. (2006)
  188. ^ Acosta S, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged ratRejuvenation Res. (2010)
  189. ^ Yasuhara T, et al. Dietary supplementation exerts neuroprotective effects in ischemic stroke modelRejuvenation Res. (2008)
  190. ^ Shytle RD, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compoundsRejuvenation Res. (2007)
  191. Torres-Duran PV, Ferreira-Hermosillo A, Juarez-Oropeza MA. Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary reportLipids Health Dis. (2007)
  192. Mazokopakis EE, et al. The hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective studyJ Sci Food Agric. (2013)
  193. Ashraf R, et al. Effects of Allium sativum (Garlic) on systolic and diastolic blood pressure in patients with essential hypertensionPak J Pharm Sci. (2013)
  194. Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysisNutr Rev. (2013)
  195. Hou LQ, Liu YH, Zhang YY. Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trialsAsia Pac J Clin Nutr. (2015)
  196. Bowtell JL, et al. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementationAppl Physiol Nutr Metab. (2017)
  197. Krikorian R, et al. Blueberry supplementation improves memory in older adultsJ Agric Food Chem. (2010)
  198. Rendeiro C, et al. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young ratsPsychopharmacology (Berl). (2012)
  199. Whyte AR, Schafer G, Williams CM. Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old childrenEur J Nutr. (2016)
  200. Potential health benefits of spirulina microalgae.
  201. Characterization of Spirulina Biomass for CELSS Diet Potential.
  202. Vitamin A.
  203. Wu Q, et al. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overviewArch Toxicol. (2016)
  204. Kerley CP. Dietary nitrate as modulator of physical performance and cardiovascular healthCurr Opin Clin Nutr Metab Care. (2017)
  205. Siervo M, et al. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysisJ Nutr. (2013)