Rhodiola Genera, Rhodiola Rosea
Rhodiola rosea roots are considered adaptogens, meaning they help your body adapt to stress when consumed. Its root contains more than 140 active ingredients, the two most potent of which are rosavin and salidroside.
- Origin: Plant Based
- Source: Itself
- Type: Herbs, Roots & Barks
- Age Range: Adults, Seniors
- Toxicity: There is no evidence of toxicity until now
- Outcomes: Muscle Health, Fatigue Prevention, Muscular Endurance
What are Rhodiola Rosea benefits?
Rhodiola Rosea, also known as arctic root or golden root, is an herb of the genus Rhodiola, in the family Crassulaceae, and is a popular herb for its ‘adaptogenic’ properties (reducing fatigue and exhaustion in prolonged stress situations). The main chemicals thought to be responsible for Rhodiola rosea’s effects are rosavin and salidroside. And according to studies, Rhodiola Rosea has shown evidence of several benefits to the body, significantly reducing fatigue and exhaustion that come from stress and anxiety. The herb was also able to show results in exercise performance, as evidence showed that acute supplementation before exercise can reduce fatigue. Mood improvement was also one of the benefits of Rhodiola Rosea consumption. In addition, Rhodiola Rosea has also been shown to be beneficial in reducing symptoms of depression, controlling diabetes, and also preventing certain types of cancer.
Table of relations
Rhodiola Rosea and Muscle Health
-
Fatigue Prevention
Fatigue is characterized by a reduction in mental energy. It can also appear as acute and/or chronic fatigue. Acute fatigue is due to excessive mentally demanding work. Chronic fatigue is multifactorial, influenced by insomnia, stress, anxiety, depression, causing tiredness and constant lack of motivation. The substances indicated for fatigue help to improve sleep and mood problems as they are neuroprotective, affecting neurological function.
-
Muscular Endurance
It is about the capacity of a muscle to repeatedly exercise during a set of movements. Compounds that improve power output are the ones which also have antifatigue effects.
Related videos about Rhodiola Rosea
References
- ^ a b c Colson SN, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res. (2005)
- ^ a b Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. (2004)
- ^ a b c Skarpanska-Stejnborn A, et al. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. (2009)
- ^ Bangratz M, et al. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate depression. Neuropsychiatr Dis Treat. (2018)
- ^ a b c d e f g h Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol. (2000)
- ^ Ha Z, et al. The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude. Zhonghua Jie He He Hu Xi Za Zhi. (2002)
- ^ Yu HL, et al. Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. (2019)
- ^ Shi ZF, et al. Three preparations of compound Chinese herbal medicines for de-adaptation to high altitude: a randomized, placebo-controlled trial. Zhong Xi Yi Jie He Xue Bao. (2011)
- ^ Xu KJ, Zhang SF, Li QX. Preventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation. Zhongguo Zhong Xi Yi Jie He Za Zhi. (2003)
- ^ Zhang S, et al. Early use of Chinese drug rhodiola compound for patients with post-trauma and inflammation in prevention of ALI/ARDS. Zhonghua Wai Ke Za Zhi. (1999)
- ^ Shen WS, Gao CH, Zhang H. Effect of rhodiola on serum troponin 1, cardiac integral backscatter and left ventricle ejective fraction of patients who received epirubicin-contained chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi. (2010)
- ^ Ballmann CG, et al. Effects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performance. J Sports Sci. (2019)
- ^ Mao Jun, et al. A Randomized Placebo Controlled Trial of Rhodiola Rosea and Sertraline for Major Depressive Disorder.
- ^ a b c d e f g h i j k l m n o p q r s t Rohloff J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry. (2002)
- ^ a b c d Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. (2010)
- ^ a b c Jafari M, et al. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. (2007)
- ^ a b c d e f g h Yousef GG, et al. Comparative phytochemical characterization of three Rhodiola species. Phytochemistry. (2006)
- ^ Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their Stress – Protective Activity.
- ^ a b c d Mudge E, et al. Purification of Phenylalkanoids and monoterpene glycosides from rhodiola rosea L. roots by high-speed counter-current chromatography. Phytochem Anal. (2013)
- ^ a b c d Akgul Y, et al. Lotaustralin from Rhodiola rosea roots. Fitoterapia. (2004)
- ^ a b c d Ming DS, et al. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res. (2005)
- ^ a b Study on separation and purification of oligomeric proanthocyanidin from Rhodiola rosea.
- ^ Extraction and purification of proanthocyanidins from R.Roaea.
- ^ Glycosides of cinnamyl alcohol from the rhizomes of Rhodiola rosea.
- ^ a b c d Guo N, et al. Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry. Molecules. (2012)
- ^ a b c Panossian A, et al. Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. Front Neurosci. (2012)
- ^ a b Darbinyan V, et al. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. (2007)
- ^ a b c Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. (2009)
- ^ a b Aslanyan G, et al. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. Phytomedicine. (2010)
- ^ a b c d Sodium-dependent Glucose Transporter Was Involved in Salidroside Absorption in Intestine of Rats.
- ^ Mizuma T, et al. Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs. Biochem Pharmacol. (1992)
- ^ Morand C, et al. Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic Res. (2000)
- ^ Yu S, et al. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study. J Chromatogr B Analyt Technol Biomed Life Sci. (2008)
- ^ Chang YW, et al. Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. (2007)
- ^ Hellum BH, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med. (2010)
- ^ Panossian A, et al. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats. Phytother Res. (2009)
- ^ a b c d Wiegant FA, et al. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. (2009)
- ^ Hormesis and aging in Caenorhabditis elegans.
- ^ McElwee JJ, et al. Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol. (2007)
- ^ Partridge L, Gems D. Mechanisms of ageing: public or private. Nat Rev Genet. (2002)
- ^ Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. (2009)
- ^ a b Schriner SE, et al. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. (2009)
- ^ Schriner SE, et al. Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. PLoS One. (2013)
- ^ Bayliak MM, Lushchak VI. The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae. Phytomedicine. (2011)
- ^ a b van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. (2009)
- ^ Inhibition of monoamine oxidase and acetylcholinesterase by Rhodiola rosea L.
- ^ a b c d e f g Mannucci C, et al. Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats. Phytomedicine. (2012)
- ^ Blum K, et al. Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis. Med Hypotheses. (2007)
- ^ Ciumaşu-Rîmbu M, Popa L, Vulpoi C. Neuropeptide Y stimulation as primary target for preventive measures of maladaptative cardiovascular reactions in occupational chronic stress exposure. Rev Med Chir Soc Med Nat Iasi. (2012)
- ^ Panossian A, et al. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. (2009)
- ^ Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res. (2005)
- ^ Sheng QS, et al. Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport. (2013)
- ^ Ma J, et al. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci Lett. (2010)
- ^ Tidwell JL, Houenou LJ, Tytell M. Administration of Hsp70 in vivo inhibits motor and sensory neuron degeneration. Cell Stress Chaperones. (2004)
- ^ Houenou LJ, et al. Exogenous heat shock cognate protein Hsc 70 prevents axotomy-induced death of spinal sensory neurons. Cell Stress Chaperones. (1996)
- ^ a b c d Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat.
- ^ a b Pretreatment with Rhodiola Rosea Extract Reduces Cognitive Impairment Induced by Intracerebroventricular Streptozotocin in Rats: Implication of Anti-oxidative and Neuroprotective Effects.
- ^ a b Effects of Rhodiola rosea extract on passive avoidance tests in rats.
- ^ Petkov VD, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg. (1986)
- ^ Lazarova MB, et al. Effects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find Exp Clin Pharmacol. (1986)
- ^ a b Zhang J, et al. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. (2013)
- ^ Qu ZQ, et al. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects. Biomed Environ Sci. (2009)
- ^ Fintelmann V, Gruenwald J. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv Ther. (2007)
- ^ a b Neuroprotective Effects of Salidroside in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation.
- ^ a b c d e Zhang L, et al. Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem Int. (2010)
- ^ a b Chen X, et al. Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons. Mol Cell Biochem. (2009)
- ^ Shi TY, et al. Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro. Neurotox Res. (2012)
- ^ Cao LL, Du GH, Wang MW. The effect of salidroside on cell damage induced by glutamate and intracellular free calcium in PC12 cells. J Asian Nat Prod Res. (2006)
- ^ Chen X, et al. Salidroside attenuates glutamate-induced apoptotic cell death in primary cultured hippocampal neurons of rats. Brain Res. (2008)
- ^ a b Palumbo DR, et al. Rhodiola rosea extract protects human cortical neurons against glutamate and hydrogen peroxide-induced cell death through reduction in the accumulation of intracellular calcium. Phytother Res. (2012)
- ^ a b Chen QG, et al. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. (2009)
- ^ Panossian A, et al. Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells. Front Neurosci. (2013)
- ^ a b Kennett GA, et al. Anxiolytic-like actions of the selective 5-HT4 receptor antagonists SB 204070A and SB 207266A in rats. Neuropharmacology. (1997)
- ^ a b c d Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. (2011)
- ^ a b c d e f g h i Spasov AA, et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. (2000)
- ^ a b c d e De Bock K, et al. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. (2004)
- ^ a b Darbinyan V, et al. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. (2000)
- ^ a b Shevtsov VA, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. (2003)
- ^ Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study. Phytother Res. (2012)
- ^ Rhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled Trial.
- ^ a b c Cifani C, et al. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating. Physiol Behav. (2010)
- ^ Mattioli L, Perfumi M. Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol. (2007)
- ^ a b Micioni Di Bonaventura MV, et al. Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats. J Obes. (2012)
- ^ Cifani C, et al. A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam. Psychopharmacology (Berl). (2009)
- ^ a b c Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res. (2007)
- ^ The Use of Herbal Adaptogens together with Tricyclic Antidepressants in Patients with Psychogenic Depressions.
- ^ Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. (2008)
- ^ Sun L, et al. Salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis. Life Sci. (2012)
- ^ Zhong H, et al. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci. (2010)
- ^ He H, et al. Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia. Cell Death Differ. (1999)
- ^ Role of the Mitochondrial Permeability Transition in Myocardial Disease.
- ^ Aggeli IK, Gaitanaki C, Beis I. Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells. Cell Signal. (2006)
- ^ a b Lee OH, et al. Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway. Phytother Res. (2011)
- ^ Wu T, et al. Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol. (2009)
- ^ Zhang J, et al. Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. Eur J Pharmacol. (2009)
- ^ Zhu Y, et al. Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway. DNA Cell Biol. (2011)
- ^ a b Cheng YZ, et al. Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats. J Ethnopharmacol. (2012)
- ^ Cheng L, et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. (2004)
- ^ Cheng L, et al. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun. (2004)
- ^ Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. (2006)
- ^ Minotti G, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. (2004)
- ^ Elliott P. Pathogenesis of cardiotoxicity induced by anthracyclines. Semin Oncol. (2006)
- ^ a b Zhang H, et al. Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer. Drugs R D. (2012)
- ^ Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. (2008)
- ^ a b c d e f Li X, et al. Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance. Blood. (2012)
- ^ a b c Qian EW, Ge DT, Kong SK. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. (2011)
- ^ Zheng KY, et al. Salidroside stimulates the accumulation of HIF-1α protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells. Eur J Pharmacol. (2012)
- ^ a b c Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr. (2006)
- ^ a b Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr. (2006)
- ^ Anti-diabetes functionality of Kefir culture-mediated fermented soymilk supplemented with Rhodiola extracts.
- ^ Wei H, et al. Behavioural study of the D-galactose induced aging model in C57BL/6J mice. Behav Brain Res. (2005)
- ^ Cui X, et al. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res. (2006)
- ^ Song X, et al. Advanced glycation in D-galactose induced mouse aging model. Mech Ageing Dev. (1999)
- ^ a b Mao GX, et al. Protective role of salidroside against aging in a mouse model induced by D-galactose. Biomed Environ Sci. (2010)
- ^ a b Li F, et al. Protective effect of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. Molecules. (2011)
- ^ Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors. (2006)
- ^ Lu L, Yuan J, Zhang S. Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats. Age (Dordr). (2012)
- ^ a b Li HB, et al. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol. (2008)
- ^ a b c Parisi A, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness. (2010)
- ^ a b c Wing SL, et al. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med. (2003)
- ^ a b Walker TB, et al. Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men. Metabolism. (2007)
- ^ a b Abidov M, et al. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull Exp Biol Med. (2004)
- ^ a b Schutgens FW, et al. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment. Phytother Res. (2009)
- ^ a b Noreen EE, et al. The Effects of an Acute Dose of Rhodiola Rosea on Endurance Exercise Performance. J Strength Cond Res. (2012)
- ^ Noreen EE, et al. The Effects of an Acute Dose of Rhodiola rosea on Endurance Exercise Performance. J Strength Cond Res. (2013)
- ^ a b c d Zhang JK, et al. Protection by Salidroside against Bone Loss via Inhibition of Oxidative Stress and Bone-Resorbing Mediators. PLoS One. (2013)
- ^ Oka S, Hsu CP, Sadoshima J. Regulation of cell survival and death by pyridine nucleotides. Circ Res. (2012)
- ^ a b c d Xu J, Li Y. Effects of salidroside on exhaustive exercise‑induced oxidative stress in rats. Mol Med Rep. (2012)
- ^ a b Schriner SE, et al. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med. (2009)
- ^ Qian EW, Ge DT, Kong SK. Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. J Nat Prod. (2012)
- ^ Qu ZQ, et al. Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat. PLoS One. (2012)
- ^ Mao GX, et al. Salidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative status. Mech Ageing Dev. (2010)
- ^ Guan S, et al. Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway. Molecules. (2011)
- ^ a b Evaluation of the medicinal botanical Rhodiola rosea for estrogenicity.
- ^ Ouyang JF, et al. In-vitro promoted differentiation of mesenchymal stem cells towards hepatocytes induced by salidroside. J Pharm Pharmacol. (2010)
- ^ Huang SC, et al. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol. (2009)
- ^ Bocharova OA, et al. The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research). Urol Nefrol (Mosk). (1995)
- ^ a b Liu Z, et al. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. (2012)
- ^ a b Hu X, et al. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem Biophys Res Commun. (2010)
- ^ a b Hu X, et al. A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol. (2010)
- ^ a b Mattioli L, Perfumi M. Evaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in mice. J Psychopharmacol. (2011)
- ^ a b Huo J, et al. Chinese medicine formula “Weikang Keli” induces autophagic cell death on human gastric cancer cell line SGC-7901. Phytomedicine. (2013)
- ^ a b Booker A, et al. The authenticity and quality of Rhodiola rosea products. Phytomedicine. (2015)
- Ross SM. Rhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigue. Holist Nurs Pract. (2014)
- Ross SM. Rhodiola rosea (SHR-5), Part 2: A standardized extract of Rhodiola rosea is shown to be effective in the treatment of mild to moderate depression. Holist Nurs Pract. (2014)
- Mao JJ, et al. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine. (2015)
- Shanely RA, et al. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain Behav Immun. (2014)
- Cropley M, Banks AP, Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytother Res. (2015)
- Punja S, et al. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial. PLoS One. (2014)
- Jówko E, et al. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. J Sport Health Sci. (2018)
- Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. (2017)
- Lekomtseva Y, Zhukova I, Wacker A. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial. Complement Med Res. (2017)
- Duncan MJ, Clarke ND. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. J Sports Med (Hindawi Publ Corp). (2014)