Valeriana officinalis, Valerian

Valerian is a plant with sweet-smelling white or pink flowers that bloom in the summer. In pharmacotherapy and herbal medicine, valerian is used as a medicine from the roots of the plant, which after the processes of maceration, grinding, and desiccation, are packaged in capsules and used as anxiolytic, tranquilizing and even anticonvulsant effects. Even as herbal medicine, high doses of valerian can cause some side effects, such as agitation and headaches.

  • Origin: Plant Based
  • Source: Itself
  • Type: Herbs, Roots & Barks
  • Age Range: Adults, Seniors
  • Toxicity: May be toxic in high doses
  • Outcomes: Cognitive Function and Brain Health, Energy and Mood, Cognitive Enhancer, Sleep Quality, Insomnia

What are Valerian benefits?

Valerian, also known as valeriana officinalis, is a plant widely used to prepare tea or consumed for relaxation and sedation purposes. According to studies, valerian has been used since ancient times to promote tranquility and improve sleep, given its sedative and anxiety-reducing effects. In addition, another benefit of valerian is about reducing menstrual pain, as it is spasmolytic.

Table of relations

Outcome
Sub-Outcome
Consistent effects
Strength of effects
Scientific articles

Cognitive Function and Brain Health Valerian and Cognitive Function and Brain Health

Cognitive functions are brain skills divided into: memory, perception, language, executive functions, attention and praxis (ability to perform complex movements). These functions depend on healthy synapses and neurons, which require good overall brain functioning. Supplements can affect cognitive performance directly or indirectly. Direct effects can alter or participate in neurotransmissions and influence the brain's energy metabolism. The indirect effects include hormonal changes that affect the brain, and improvements in cognitive disorders such as anxiety, depression and insomnia.
  • Cognitive Enhancer

    Cognition encompasses many factors, such as thinking, language, perception, and memory. When talking about cognitive improvement, we define age-related decline in cognitive health as something common, however, knowing which habits negatively influence it and how to prevent any loss in these areas is important. In addition to age, factors such as injury, family history, or bad habits can influence the decline to some degree of the sectors involved. Several studies associate nutrition with the improvement of brain and cognitive function; the ingestion of nutraceuticals for this purpose optimizes this process and guarantees results with scientific proof.

Energy and Mood Valerian and Energy and Mood

Energy and mood are associated with several external and internal factors. Hormone release, brain chemical balance, nutrient metabolism, and several other elements alter the way the body and mind respond to daily activities. The compounds that benefit energy and mood are the ones that help in the balance of all these factors.
  • Sleep Quality

    Sleep is a very important physiological process, as it regulates the body's functions. It is responsible for promoting / facilitating energy conservation, synthesis and secretion of hormones and proteins, learning and memory through brain changes. Sleep is mainly driven by the circadian cycle, which involves exposure to light, hormones such as melatonin, and hypothalamic activity. The compounds that help regulate sleep work in different pathways, they can facilitate the process of falling asleep, increase the duration of continuous sleep or improve the quality of sleep.

  • Insomnia

    Sleep is essential for good health and survival, without this period of rest several functions of our body would not work properly: deregulating the mood, causing pain, inattention, and even recent memory loss. Insomnia is the absence of sleep or the recent awakening in the middle of the night, and can be a symptom or a disease. Even if insomnia is something common to everyone and results from isolated events, the frequency of this disorder must be treated to avoid further problems.

Table of negative interactions

Drugs
Acetylcarbromal, Alfentanil, Alprazolam, Amitriptyline, Amobarbital, Amoxapine, Apomorphine, Aripiprazole, Asenapine, Azatadine, Baclofen, Benztropine, Biperiden, Brexanolone, Brexpiprazole, Brivaracetam, Bromocriptine, Brompheniramine, Buprenorphine, Buspirone, Butabarbital, Butalbital, Butorphanol, Cannabidiol, Cannabis, Carbamazepine, Carbetapentane, Carbinoxamine, Cariprazine, Carisoprodol, Cenobamate, Cetirizine, Chlophedianol, Chloral Hydrate, Chlordiazepoxide, Chlormezanone, Chlorphenesin, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Citalopram, Clemastine, Clobazam, Clomipramine, Clonazepam, Clonidine, Clorazepate, Clozapine, Codeine, Cyclizine, Cyclobenzaprine, Cyproheptadine, Dantrolene, Desipramine, Desvenlafaxine, Deutetrabenazine, Dexbrompheniramine, Dexchlorpheniramine, Dexmedetomidine, Dextromethorphan, Dezocine, Diazepam, Dimenhydrinate, Diphenhydramine, Doxepin, Doxepin Topical, Doxylamine, Dronabinol, Droperidol, Duloxetine, Entacapone, Escitalopram, Esketamine, Eslicarbazepine, Estazolam, Eszopiclone, Ethchlorvynol, Ethosuximide, Ethotoin, Ezogabine, Felbamate, Fentanyl, Flavoxate, Flibanserin, Fluoxetine, Fluphenazine, Flurazepam, Fluvoxamine, Fosphenytoin, Gabapentin, Halazepam, Haloperidol, Hydrocodone, Hydromorphone, Hydroxyzine, Ifosfamide, Iloperidone, Imipramine, Isocarboxazid, Ketamine, Lamotrigine, Lasmiditan, Lemborexant, Levetiracetam, Levocetirizine, Levorphanol, Lithium, Lofexidine, Lorazepam, Loxapine, Lumateperone, Lurasidone, Maprotiline, Meclizine, Meperidine, Mephenytoin, Mephobarbital, Meprobamate, Mesoridazine, Metaxalone, Methadone, Methdilazine, Methocarbamol, Methotrimeprazine, Methsuximide, Metoclopramide, Metyrosine, Midazolam, Mirtazapine, Molindone, Morphine, Nabilone, Nalbuphine, Nefazodone, Nortriptyline, Olanzapine, Oliceridine, Opicapone, Opium, Orphenadrine, Oxazepam, Oxcarbazepine, Oxycodone, Oxymorphone, Paliperidone, Paraldehyde, Paramethadione, Paroxetine, Pentazocine, Pentobarbital, Perampanel, Pergolide, Perphenazine, Phenacemide, Phenelzine, Phenindamine, Phenobarbital, Phensuximide, Phenytoin, Pimozide, Pramipexole, Prochlorperazine, Procyclidine, Promazine, Promethazine, Propiomazine, Protriptyline, Pyrilamine, Quazepam, Quetiapine, Ramelteon, Rasagiline, Remifentanil, Remimazolam, Risperidone, Ropinirole, Rotigotine, Rufinamide, Secobarbital, Sertraline, Sibutramine, Stiripentol, Sufentanil, Suvorexant, Tapentadol, Tasimelteon, Temazepam, Tetrabenazine, Thalidomide, Thiethylperazine, Thiopental, Thioridazine, Thiothixene, Tiagabine, Tizanidine, Tolcapone, Topiramate, Tramadol, Tranylcypromine, Trazodone, Triazolam, Trifluoperazine, Trihexyphenidyl, Trimeprazine, Trimethadione, Trimethobenzamide, Trimipramine, Tripelennamine, Triprolidine, Valbenazine, Venlafaxine, Vigabatrin, Zaleplon, Ziconotide, Ziprasidone, Zolpidem, Zonisamide

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References

  1. a b Maroo N, Hazra A, Das T. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trialIndian J Pharmacol. (2013)
  2. a b Taavoni S, Nazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopauseComplement Ther Clin Pract. (2013)
  3. a b Houghton PJ. The scientific basis for the reputed activity of ValerianJ Pharm Pharmacol. (1999)
  4. ^ Salter S, Brownie S. Treating primary insomnia – the efficacy of valerian and hopsAust Fam Physician. (2010)
  5. ^ Mathela CS, et al. Valeriana wallichii DC, a new chemotype from northwestern HimalayaJ Essent Oil Res. (2005)
  6. a b c d e f g h i Navarrete A, et al. Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detectionJ AOAC Int. (2006)
  7. a b c Donovan JL, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteersDrug Metab Dispos. (2004)
  8. a b c Del Valle-Mojica LM, et al. Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with {H}Glutamate Binding to Rat Synaptic MembranesEvid Based Complement Alternat Med. (2011)
  9. a b c d e f g h i Schumacher B, et al. Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptorsJ Nat Prod. (2002)
  10. ^ Bodesheim U, Hölzl J. Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis LPharmazie. (1997)
  11. ^ Wang PC, et al. Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalisTetrahedron Lett. (2010)
  12. a b c d e Marder M, et al. 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNSPharmacol Biochem Behav. (2003)
  13. a b c d e f g Fernández S, et al. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalisPharmacol Biochem Behav. (2004)
  14. a b Goppel M, Franz G. Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignansPharmazie. (2004)
  15. ^ Taibi DM, Bourguignon C, Gill Taylor A. A feasibility study of valerian extract for sleep disturbance in person with arthritisBiol Res Nurs. (2009)
  16. a b c d e f g h i Fernández-San-Martín MI, et al. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trialsSleep Med. (2010)
  17. a b c d Barton DL, et al. The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5)J Support Oncol. (2011)
  18. ^ Balderer G, Borbély AA. Effect of valerian on human sleepPsychopharmacology (Berl). (1985)
  19. a b c Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in manPlanta Med. (1985)
  20. a b c d e f g h i j Abourashed EA, Koetter U, Brattström A. In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptorsPhytomedicine. (2004)
  21. a b c Müller CE, et al. Interactions of valerian extracts and a fixed valerian-hop extract combination with adenosine receptorsLife Sci. (2002)
  22. ^ Melzer J, et al. Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trialPhytother Res. (2009)
  23. a b c Hellum BH, Hu Z, Nilsen OG. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytesBasic Clin Pharmacol Toxicol. (2007)
  24. a b Hellum BH, Hu Z, Nilsen OG. Trade herbal products and induction of CYP2C19 and CYP2E1 in cultured human hepatocytesBasic Clin Pharmacol Toxicol. (2009)
  25. a b c Gurley BJ, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypesClin Pharmacol Ther. (2005)
  26. ^ Budzinski JW, et al. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tincturesPhytomedicine. (2000)
  27. ^ Mohamed ME, Frye RF. Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activitiesDrug Metab Dispos. (2011)
  28. a b c d e f g h i Dietz BM, et al. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitroBrain Res Mol Brain Res. (2005)
  29. ^ Del Valle-Mojica LM, Ortíz JG. Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptorsPlanta Med. (2012)
  30. ^ Bergink V, van Megen HJ, Westenberg HG. Glutamate and anxietyEur Neuropsychopharmacol. (2004)
  31. ^ Swanson CJ, et al. Metabotropic glutamate receptors as novel targets for anxiety and stress disordersNat Rev Drug Discov. (2005)
  32. a b Yuan CS, et al. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activityAnesth Analg. (2004)
  33. ^ Cavadas C, et al. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brainArzneimittelforschung. (1995)
  34. a b c d Khom S, et al. Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificityNeuropharmacology. (2007)
  35. a b c d Benke D, et al. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extractsNeuropharmacology. (2009)
  36. a b c d Trauner G, et al. Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acidPlanta Med. (2008)
  37. ^ Wasowski C, et al. Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichiiPlanta Med. (2002)
  38. ^ Mayer B, Springer E. Psychoexperimental studies on the effect of a valepotriate combination as well as the combined effects of valtratum and alcoholArzneimittel-Forschung. (1974)
  39. ^ Chambers J, et al. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1Nature. (1999)
  40. ^ Vissiennon Z, et al. Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neuronsPlanta Med. (2006)
  41. a b c Rezvani ME, et al. Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosineJ Ethnopharmacol. (2010)
  42. ^ Rezvani ME, et al. Anticonvulsant effect of A1 but not A2A adenosine receptors of piriform cortex in amygdala-kindled ratsCan J Physiol Pharmacol. (2007)
  43. ^ Hosseinmardi N, et al. The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in ratsPharmacol Res. (2007)
  44. ^ Miyasaka LS, Atallah AN, Soares BG. Valerian for anxiety disordersCochrane Database Syst Rev. (2006)
  45. a b Felgentreff F, et al. Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activityPhytomedicine. (2012)
  46. ^ Andreatini R, et al. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot studyPhytother Res. (2002)
  47. ^ Jacobs BP, et al. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomniaMedicine (Baltimore). (2005)
  48. a b Taibi DM, et al. A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomniaSleep Med. (2009)
  49. ^ Leathwood PD, et al. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in manPharmacol Biochem Behav. (1982)
  50. ^ Leathwood PD, Chauffard F. Quantifying the effects of mild sedativesJ Psychiatr Res. (1982-1983)
  51. ^ Schulz H, Stolz C, Müller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot studyPharmacopsychiatry. (1994)
  52. ^ Donath F, et al. Critical evaluation of the effect of valerian extract on sleep structure and sleep qualityPharmacopsychiatry. (2000)
  53. a b Francis AJ, Dempster RJ. Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trialPhytomedicine. (2002)
  54. ^ Poyares DR, et al. Can valerian improve the sleep of insomniacs after benzodiazepine withdrawalProg Neuropsychopharmacol Biol Psychiatry. (2002)
  55. ^ Diaper A, Hindmarch I. A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adultsPhytother Res. (2004)
  56. ^ Bent S, et al. Valerian for sleep: a systematic review and meta-analysisAm J Med. (2006)
  57. ^ Taibi DM, et al. A systematic review of valerian as a sleep aid: safe but not effectiveSleep Med Rev. (2007)
  58. ^ Stevinson C, Ernst E. Valerian for insomnia: a systematic review of randomized clinical trialsSleep Med. (2000)
  59. ^ Sarris J, Byrne GJ. A systematic review of insomnia and complementary medicineClin Rev. (2011)
  60. ^ Roth T, Roehrs T. Efficacy and Safety of Sleep-Promoting AgentsSleep Med Clin. (2008)
  61. a b Pakseresht S, Boostani H, Sayyah M. Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind studyJ Complement Integr Med. (2011)
  62. a b Nam SM, et al. Valeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidationExp Gerontol. (2013)
  63. ^ Wheatley D. Kava and valerian in the treatment of stress-induced insomniaPhytother Res. (2001)
  64. ^ Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problemJ Clin Oncol. (2001)
  65. ^ Palesh OG, et al. Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology ProgramJ Clin Oncol. (2010)
  66. ^ Davidson JR, et al. Sleep disturbance in cancer patientsSoc Sci Med. (2002)
  67. ^ Miller AH, et al. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancerJ Clin Oncol. (2008)
  68. ^ Singh A, et al. Prevalence and severity of dysmenorrhea: a problem related to menstruation, among first and second year female medical studentsIndian J Physiol Pharmacol. (2008)
  69. ^ Unsal A1, et al. Prevalence of dysmenorrhea and its effect on quality of life among a group of female university studentsUps J Med Sci. (2010)
  70. ^ Tavallaee M, et al. The prevalence of menstrual pain and associated risk factors among Iranian womenJ Obstet Gynaecol Res. (2011)
  71. ^ Gilani AH, et al. Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activationJ Ethnopharmacol. (2005)
  72. ^ Mirabi P, et al. Effects of valerian on the severity and systemic manifestations of dysmenorrheaInt J Gynaecol Obstet. (2011)
  73. a b Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal womenIran J Pharm Res. (2013)
  74. ^ Taavoni S, et al. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trialMenopause. (2011)
  75. ^ Bhatt C, et al. Synergistic potentiation of anti-anxiety activity of valerian and alprazolam by liquoriceIndian J Pharmacol. (2013)
  76. ^ Cuellar NG, Ratcliffe SJ. Does valerian improve sleepiness and symptom severity in people with restless legs syndromeAltern Ther Health Med. (2009)
  77. ^ Takeshita S, Takeshita J. A case of hyponatremia due to self-treatment of anxiety with a beverage containing valerian rootPrim Care Companion CNS Disord. (2013)
  78. Behboodi Moghadam Z, et al. The effect of Valerian root extract on the severity of pre menstrual syndrome symptomsJ Tradit Complement Med. (2016)