Selenium, Selenium
Selenium is a mineral with a high antioxidant power, helping to prevent diseases such as cancer and strengthening the immune system, in addition to protecting the body against cardiovascular diseases, such as atherosclerosis.
- Origin: Plant Based, Animal Product
- Source: Eggs, Meat, Fish, Beans, Oatmeal, Brazil Nuts, Sunflower Seeds
- Type: Mineral
- Age Range: Adults, Seniors
- Toxicity: May be toxic in high doses
- Outcomes: Immunity, Men’s Health, Women’s Health, Immune Booster, Sperm Quality, Pregnancy
What are Selenium benefits?
Selenium is considered to be one of the essential minerals for the development and maintenance of the human body since the body incorporates selenium into special types of proteins called ‘selenoproteins’. Selenoproteins are needed for important functions in the body, such as the production of thyroid hormones. Remember that selenium is found in certain animal and plant foods, including meats, grains, Brazil nuts, fish, and eggs. In addition, selenium has antioxidant and anti-inflammatory properties, and according to research, may have a number of health benefits, such as improved immune system, prevention of mental decline, protection against heart disease, reduced risk of certain types of cancer, reduced symptoms of asthma, and also in reducing symptoms related to certain health conditions such as autoimmune thyroid disease.
Table of relations
Selenium and Immunity
-
Immune Booster
The immune system is responsible for defense against infectious agents, and is composed of leukocytes, macrophages, and lymphocytes. When immunity levels are low, the body is more likely to become infected with viruses, bacteria, and others. People who are easily infected can have low immunity for various reasons, such as family history diseases, poor diet, or absorption difficulties in some body function. Maintaining the intake of substances that strengthen immunity is to prevent diseases and prepare the body for any possible infection. To do this, it is important to turn your attention to what is ingested, exercise habits, and supplementation.
Selenium and Men's Health
A man's health is the result of various habits throughout his life, such as diet, exercise, vaccinations, routine exams, and family history. Male health has biological differences from female health, such as: hormone levels, sexual life and libido, and the cognitive system. Keeping your body healthy requires discipline and attention to monitoring, because these differences require specific care and solutions for a balanced body. Nutraceuticals can help all areas of man's health to function in harmony, from the extraction of vitamins, minerals, and other substances from nature's plants, fruits, and herbs, they boost the good performance of every part of the body.
-
Sperm Quality
The quality of the sperm is directly related to the strength that the sperm possesses. This property of the male gamete is influenced by diet and can change with nutritional levels.Male infertility is - for the most part - caused by problems in the concentration, strength of movement, and structure of the sperm. There are several vitamins that help the quality of the sperm and thus increase the chances of fecundation; due to the difficulty of ingesting all of them daily, supplementation is a good option.
Selenium and Women's Health
-
Pregnancy
During pregnancy, it is natural for the baby to feed on whatever is ingested by the mother, so the mother's diet should be multivitamin for her body and that of the child. A varied and healthy diet should provide the nutrients necessary for good health, however, supplementation compensates for possible deficiencies and boosts the levels of certain substances in the ever-changing body.
Table of negative interactions
Related videos about Selenium
References
- ^ a b c Schrauzer GN. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr. (2000)
- ^ Yamashita Y, Yabu T, Yamashita M. Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism. World J Biol Chem. (2010)
- ^ a b Winkel LH, et al. Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review. Nutrients. (2015)
- ^ a b c d Navarro-Alarcon M, Cabrera-Vique C. Selenium in food and the human body: a review. Sci Total Environ. (2008)
- ^ Thomson CD, et al. Brazil nuts: an effective way to improve selenium status. Am J Clin Nutr. (2008)
- ^ Pappa EC, Pappas AC, Surai PF. Selenium content in selected foods from the Greek market and estimation of the daily intake. Sci Total Environ. (2006)
- ^ Barclay MNI, MacPherson A, Dixon J. Selenium Content of a Range of UK Foods. J Food Compost Anal. (1995)
- ^ Papp LV, et al. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. (2007)
- ^ a b c Rayman MP. Selenium and human health. Lancet. (2012)
- ^ Mustacich D, Powis G. Thioredoxin reductase. Biochem J. (2000)
- ^ May JM, et al. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J Biol Chem. (1998)
- ^ Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids.
- ^ a b Letavayová L, Vlcková V, Brozmanová J. Selenium: from cancer prevention to DNA damage. Toxicology. (2006)
- ^ Chen J. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nutr. (2012)
- ^ Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. (2014)
- ^ Stadtman TC. Discoveries of vitamin B12 and selenium enzymes. Annu Rev Biochem. (2002)
- ^ Moghadaszadeh B, Beggs AH. Selenoproteins and their impact on human health through diverse physiological pathways. Physiology (Bethesda). (2006)
- ^ Rayman MP. Selenoproteins and human health: insights from epidemiological data. Biochim Biophys Acta. (2009)
- ^ Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc. (2005)
- ^ Combs GF Jr, Clark LC, Turnbull BW. An analysis of cancer prevention by selenium. Biofactors. (2001)
- ^ Schrauzer GN. Nutritional selenium supplements: product types, quality, and safety. J Am Coll Nutr. (2001)
- ^ a b Reid ME, et al. A report of high-dose selenium supplementation: response and toxicities. J Trace Elem Med Biol. (2004)
- ^ Whanger PD. Selenium and its relationship to cancer: an update. Br J Nutr. (2004)
- ^ a b c Brozmanová J, et al. Selenium: a double-edged sword for defense and offence in cancer. Arch Toxicol. (2010)
- ^ Suzuki KT, Kurasaki K, Suzuki N. Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide. Biochim Biophys Acta. (2007)
- ^ Seitomer E, et al. Analysis of Saccharomyces cerevisiae null allele strains identifies a larger role for DNA damage versus oxidative stress pathways in growth inhibition by selenium. Mol Nutr Food Res. (2008)
- ^ Ip C, et al. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res. (2000)
- ^ Stapleton SR. Selenium: an insulin-mimetic. Cell Mol Life Sci. (2000)
- ^ The Insulin-Like effects of Selenate in Rat Adipocytes.
- ^ Fürnsinn C, et al. Insulin-like vs. non-insulin-like stimulation of glucose metabolism by vanadium, tungsten, and selenium compounds in rat muscle. Life Sci. (1996)
- ^ Ghosh R, Mukherjee B, Chatterjee M. A novel effect of selenium on streptozotocin-induced diabetic mice. Diabetes Res. (1994)
- ^ Laclaustra M, et al. Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environ Health Perspect. (2009)
- ^ a b c Stranges S, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. (2007)
- ^ Selenium and Diabetes: More Bad News for Supplements.
- ^ Fridlyand LE, Philipson LH. Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches. Ann N Y Acad Sci. (2005)
- ^ Introduction: The selenium conundrum.
- ^ Mao J, et al. No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration. Br J Nutr. (2016)
- ^ Kosanovic M, et al. Maternal and fetal cadmium and selenium status in normotensive and hypertensive pregnancy. Biol Trace Elem Res. (2002)
- ^ Molnar J, et al. Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy. Biol Trace Elem Res. (2008)
- ^ Kilinc M, et al. Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls. Biol Trace Elem Res. (2008)
- ^ Tan M, et al. Changes of serum selenium in pregnant women with gestational diabetes mellitus. Biol Trace Elem Res. (2001)
- ^ a b Tara F, et al. Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: a randomized, double-blind, placebo-controlled pilot trial. Taiwan J Obstet Gynecol. (2010)
- ^ a b c Askari G, et al. The association between serum selenium and gestational diabetes mellitus: a systematic review and meta-analysis. J Trace Elem Med Biol. (2015)
- ^ Shamberger RJ, Frost DV. Possible protective effect of selenium against human cancer. Can Med Assoc J. (1969)
- ^ Spallholz JE, Palace VP, Reid TW. Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids. Biochem Pharmacol. (2004)
- ^ Kim A, et al. Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells. J Cell Physiol. (2007)
- ^ Valko M, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. (2007)
- ^ Valko M, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. (2006)
- ^ Valko M, et al. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. (2004)
- ^ Hu YJ, et al. Allelic loss at the GPx-1 locus in cancer of the head and neck. Biol Trace Elem Res. (2004)
- ^ Ichimura Y, et al. Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant. J Urol. (2004)
- ^ Hu YJ, Diamond AM. Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. Cancer Res. (2003)
- ^ Moscow JA, et al. Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer. Carcinogenesis. (1994)
- ^ Al-Taie OH, et al. Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutr Cancer. (2004)
- ^ Mörk H, et al. Inverse mRNA expression of the selenocysteine-containing proteins GI-GPx and SeP in colorectal adenomas compared with adjacent normal mucosa. Nutr Cancer. (2000)
- ^ Calvo A, et al. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Res. (2002)
- ^ Méplan C, et al. Relative abundance of selenoprotein P isoforms in human plasma depends on genotype, se intake, and cancer status. Antioxid Redox Signal. (2009)
- ^ Hu YJ, et al. Distribution and functional consequences of nucleotide polymorphisms in the 3′-untranslated region of the human Sep15 gene. Cancer Res. (2001)
- ^ Kumaraswamy E, et al. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. J Biol Chem. (2000)
- ^ Jablonska E, et al. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism. Eur J Nutr. (2008)
- ^ Lincoln DT, et al. The thioredoxin-thioredoxin reductase system: over-expression in human cancer. Anticancer Res. (2003)
- ^ Gladyshev VN, et al. Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun. (1998)
- ^ a b Babaknejad N, et al. The relationship between selenium levels and breast cancer: a systematic review and meta-analysis. Biol Trace Elem Res. (2014)
- ^ a b Hurst R, et al. Selenium and prostate cancer: systematic review and meta-analysis. Am J Clin Nutr. (2012)
- ^ a b Kristal AR1, et al. Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk. J Natl Cancer Inst. (2014)
- ^ a b Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. (2012)
- ^ Sahib A, et al. Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne. J Clin Exp Dermatol Res. (2012)
- ^ a b Yang L, et al. Selenium and Iodine Levels in Subjects with Kashin-Beck Disease: a Meta-analysis. Biol Trace Elem Res. (2016)
- ^ a b c d Yao Y, Pei F, Kang P. Selenium, iodine, and the relation with Kashin-Beck disease. Nutrition. (2011)
- ^ Sun LY, et al. Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kaschin-Beck disease: an epidemiological intervention trial in the Qinghai Province. Osteoarthritis Cartilage. (2014)
- ^ Eiland E, Nzure C, Faulkner M. Preeclampsia 2012. J Pregnancy. (2012)
- ^ Al-Jameil N, et al. A brief overview of preeclampsia. J Clin Med Res. (2014)
- ^ Vanderlelie J, Venardos K, Perkins AV. Selenium deficiency as a model of experimental pre-eclampsia in rats. Reproduction. (2004)
- ^ Vanderlelie J, Perkins AV. Selenium and preeclampsia: A global perspective. Pregnancy Hypertens. (2011)
- ^ Mistry HD, et al. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension. (2008)
- ^ Farzin L, Sajadi F. Comparison of serum trace element levels in patients with or without pre-eclampsia. J Res Med Sci. (2012)
- ^ Maleki A, et al. The relationship between plasma level of Se and preeclampsia. Hypertens Pregnancy. (2011)
- ^ a b Rayman MP, Bode P, Redman CW. Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom. Am J Obstet Gynecol. (2003)
- ^ Rayman MP, et al. Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. Br J Nutr. (2014)
- ^ Xu M, et al. Selenium and Preeclampsia: a Systematic Review and Meta-analysis. Biol Trace Elem Res. (2016)
- ^ Mistry HD, Broughton Pipkin F, Kurlak LO. Letter Regarding: Selenium and Preeclampsia: A Systemic Review and Meta-Analysis. Biol Trace Elem Res. (2016)
- ^ a b Valdiglesias V, et al. In vitro evaluation of selenium genotoxic, cytotoxic, and protective effects: a review. Arch Toxicol. (2010)
- ^ Biswas S, Talukder G, Sharma A. Chromosome damage induced by selenium salts in human peripheral lymphocytes. Toxicol In Vitro. (2000)
- ^ Wycherly BJ, Moak MA, Christensen MJ. High dietary intake of sodium selenite induces oxidative DNA damage in rat liver. Nutr Cancer. (2004)
- ^ Yang G, Zhou R. Further observations on the human maximum safe dietary selenium intake in a seleniferous area of China. J Trace Elem Electrolytes Health Dis. (1994)
- ^ Steven Morris J, Stampfer MJ, Willett W. Dietary selenium in humans toenails as an indicator. Biol Trace Elem Res. (1983)
- ^ Hunter DJ, et al. Predictors of selenium concentration in human toenails. Am J Epidemiol. (1990)
- ^ van den Brandt PA, et al. Predictors of toenail selenium levels in men and women. Cancer Epidemiol Biomarkers Prev. (1993)
- ^ Longnecker MP, et al. A 1-y trial of the effect of high-selenium bread on selenium concentrations in blood and toenails. Am J Clin Nutr. (1993)
- ^ Vinceti M, et al. Adverse health effects of selenium in humans. Rev Environ Health. (2001)
- ^ Winther KH, et al. Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol. (2015)
- ^ Stranges S, et al. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. (2010)
- ^ Faghihi T, et al. A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile. Am J Ther. (2014)
- ^ MacFarquhar JK, et al. Acute selenium toxicity associated with a dietary supplement. Arch Intern Med. (2010)
- ^ Morris JS, Crane SB. Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor. Nutrients. (2013)
- ^ Prevost N, English JC 3rd. Xanthotrichia (yellow hair) due to selenium sulfide and dihydroxyacetone. J Drugs Dermatol. (2008)