Resveratrol

References

1. ^ Davies M, Roulleau J. Statement of retraction. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkB. Free Radic Res. (2012)
2. ^ Das S, et al. Resveratrol-mediated activation of cAMP response element-binding protein through adenosine A3 receptor by Akt-dependent and -independent pathways. J Pharmacol Exp Ther. (2005)
3. ^ Gorbunov N, et al. Regeneration of infarcted myocardium with resveratrol-modified cardiac stem cells. J Cell Mol Med. (2012)
4. ^ Juhasz B, Mukherjee S, Das DK. Hormetic response of resveratrol against cardioprotection. Exp Clin Cardiol. (2010)
5. ^ Mukhopadhyay P, et al. Restoration of altered microRNA expression in the ischemic heart with resveratrol. PLoS One. (2010)
6. ^ Mukherjee S, Dudley JI, Das DK. Dose-dependency of resveratrol in providing health benefits. Dose Response. (2010)
7. ^ Das S, et al. Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. Am J Physiol Heart Circ Physiol. (2005)
8. ^ Das S, Fraga CG, Das DK. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB. Free Radic Res. (2006)
9. ^ Gurusamy N, et al. Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium. J Cell Mol Med. (2010)
10. ^ Bertelli A, et al. Analgesic resveratrol. Antioxid Redox Signal. (2008)
11. ^ Mukherjee S, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med. (2009)
12. ^ Lekli I, Ray D, Das DK. Longevity nutrients resveratrol, wines and grapes. Genes Nutr. (2010)
13. ^ Lekli I, et al. Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. J Cell Mol Med. (2010)
14. ^ Gurusamy N, et al. Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res. (2010)
15. ^ a b Fujitaka K, et al. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Nutr Res. (2011)
16. ^ Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron Artery Dis. (1997)
17. ^ Lippi G, et al. Moderate red wine consumption and cardiovascular disease risk: beyond the “French paradox”. Semin Thromb Hemost. (2010)
18. ^ Mezzano D, et al. Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis. Eur J Clin Nutr. (2003)
19. ^ Mezzano D, et al. Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors. Eur J Clin Nutr. (2001)
20. ^ Zamora-Ros R, et al. Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. Br J Nutr. (2008)
21. ^ Delmas D, et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets. (2006)
22. ^ Timperio AM, et al. Production of the phytoalexins trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions. Plant Physiol Biochem. (2012)
23. ^ Liang Z, et al. Characterization of polyphenolic metabolites in the seeds of Vitis germplasm. J Agric Food Chem. (2012)
24. ^ Tříska J, et al. Separation and identification of highly fluorescent compounds derived from trans-resveratrol in the leaves of Vitis vinifera infected by Plasmopara viticola. Molecules. (2012)
25. ^ Concentration of the Phytoalexin Resveratrol in Wine.
26. ^ a b c d Huang X, Mazza G. Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry. J Chromatogr A. (2011)
27. ^ Diaz LE, et al. Antioxidant, Antitubercular and Cytotoxic Activities of Piper imperiale. Molecules. (2012)
28. ^ Poulose SM, et al. Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. J Agric Food Chem. (2012)
29. ^ Sobolev VS, Cole RJ. trans-resveratrol content in commercial peanuts and peanut products. J Agric Food Chem. (1999)
30. ^ Rius C, et al. Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation. J Immunol. (2010)
31. ^ Anisimova NY, et al. Trans-, cis-, and dihydro-resveratrol: a comparative study. Chem Cent J. (2011)
32. ^ Orallo F. Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Curr Med Chem. (2006)
33. ^ Leiro J, et al. Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes. J Leukoc Biol. (2004)
34. ^ Fabbrocini G, et al. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol. (2011)
35. ^ a b Belguendouz L, Fremont L, Linard A. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem Pharmacol. (1997)
36. ^ Lappalainen Z. Sirtuins: a family of proteins with implications for human performance and exercise physiology. Res Sports Med. (2011)
37. ^ Rahman S, Islam R. Mammalian Sirt1: insights on its biological functions. Cell Commun Signal. (2011)
38. ^ Milner J. Cellular regulation of SIRT1. Curr Pharm Des. (2009)
39. ^ Verdin E, et al. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. (2010)
40. ^ Li X, Kazgan N. Mammalian sirtuins and energy metabolism. Int J Biol Sci. (2011)
41. ^ White AT, Schenk S. NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. (2012)
42. ^ Kelly G. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 1. Altern Med Rev. (2010)
43. ^ Kelly GS. A review of the sirtuin system, its clinical implications, and the potential role of dietary activators like resveratrol: part 2. Altern Med Rev. (2010)
44. ^ a b c d e f g Agarwal B, Baur JA. Resveratrol and life extension. Ann N Y Acad Sci. (2011)
45. ^ Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. (2003)
46. ^ Kaeberlein M, et al. Substrate-specific activation of sirtuins by resveratrol. J Biol Chem. (2005)
47. ^ Pacholec M, et al. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem. (2010)
48. ^ Beher D, et al. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des. (2009)
49. ^ SIRT1 activation by small molecules – kinetic and biophysical evidence for direct interaction of enzyme and activator.
50. ^ Hawley SA, et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. (2010)
51. ^ AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
52. ^ Park CE, et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med. (2007)
53. ^ Resveratrol stimulates AMP kinase activity in neurons.
54. ^ Cantó C, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. (2009)
55. ^ a b c Price NL, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. (2012)
56. ^ Lan F, et al. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. (2008)
57. ^ Hou X, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. (2008)
58. ^ a b c Park SJ, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. (2012)
59. ^ Feige JN, et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. (2008)
60. ^ a b Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle.
61. ^ a b Gerhart-Hines Z, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. (2007)
62. ^ Rodgers JT, et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. (2005)
63. ^ Jäger S, et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A. (2007)
64. ^ Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. (2011)
65. ^ a b c d Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. (2004)
66. ^ a b c d Cottart CH, et al. Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res. (2010)
67. ^ a b c d e f g h i j Howells LM, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases–safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res (Phila). (2011)
68. ^ a b c Almeida L, et al. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res. (2009)
69. ^ Chaudhary A, et al. Multiple-dose lorazepam kinetics: shuttling of lorazepam glucuronide between the circulation and the gut during day- and night-time dosing intervals in response to feeding. J Pharmacol Exp Ther. (1993)
70. ^ Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model.
71. ^ Ho KJ. Circadian rhythmic hepatic biliary flow, constituents, concentrations and excretory rates in patients after cholecystectomy. Chronobiologia. (1994)
72. ^ Vaz-da-Silva M, et al. Effect of food on the pharmacokinetic profile of trans-resveratrol. Int J Clin Pharmacol Ther. (2008)
73. ^ la Porte C, et al. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Clin Pharmacokinet. (2010)
74. ^ De Santi C, et al. Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica. (2000)
75. ^ Soleas GJ, Yan J, Goldberg DM. Measurement of trans-resveratrol, (+)-catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection. Methods Enzymol. (2001)
76. ^ Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection.
77. ^ a b Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health–a comprehensive review of human clinical trials. Mol Nutr Food Res. (2011)
78. ^ a b De Santi C, et al. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica. (2000)
79. ^ Pacifici GM. Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature. Int J Clin Pharmacol Ther. (2004)
80. ^ a b c d Boocock DJ, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev. (2007)
81. ^ a b c Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study.
82. ^ Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.
83. ^ Brown VA, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. (2010)
84. ^ a b Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem. (2003)
85. ^ Gresele P, et al. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. J Nutr. (2008)
86. ^ Soleas GJ, Yan J, Goldberg DM. Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr B Biomed Sci Appl. (2001)
87. ^ Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. (2005)
88. ^ A Global Survey of Trans-Resveratrol Concentrations in Commercial Wines.
89. ^ a b c Wu JM, Hsieh TC, Wang Z. Cardioprotection by resveratrol: a review of effects/targets in cultured cells and animal tissues. Am J Cardiovasc Dis. (2011)
90. ^ Khan MA, Muzammil S, Musarrat J. Differential binding of tetracyclines with serum albumin and induced structural alterations in drug-bound protein. Int J Biol Macromol. (2002)
91. ^ a b Jannin B, et al. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol. (2004)
92. ^ Belguendouz L, Frémont L, Gozzelino MT. Interaction of transresveratrol with plasma lipoproteins. Biochem Pharmacol. (1998)
93. ^ Curry S, Brick P, Franks NP. Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim Biophys Acta. (1999)
94. ^ a b c Lançon A, et al. Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process. Biochem Biophys Res Commun. (2004)
95. ^ a b c Wang Q, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. (2002)
96. ^ a b Bertelli A, et al. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res. (1998)
97. ^ a b Vitrac X, et al. Distribution of (14C)-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci. (2003)
98. ^ Camont L, et al. Radical-induced oxidation of trans-resveratrol. Biochimie. (2012)
99. ^ a b c Bass TM, et al. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev. (2007)
100. ^ Wang C, et al. The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr). (2011)
101. ^ Bauer JH, et al. Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc Natl Acad Sci U S A. (2007)
102. ^ Bauer JH, et al. dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging (Albany NY). (2009)
103. ^ a b c d e f Antosh M, et al. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle. (2011)
104. ^ a b Flatt T, Tu MP, Tatar M. Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays. (2005)
105. ^ a b Chandrashekara KT, Shakarad MN. Aloe vera or resveratrol supplementation in larval diet delays adult aging in the fruit fly, Drosophila melanogaster. J Gerontol A Biol Sci Med Sci. (2011)
106. ^ Frankel S, Ziafazeli T, Rogina B. dSir2 and longevity in Drosophila. Exp Gerontol. (2011)
107. ^ Labbé A, et al. Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci. (2011)
108. ^ Miller RA, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. (2011)
109. ^ Pearson KJ, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. (2008)
110. ^ Barger JL, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS One. (2008)
111. ^ Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. (2006)
112. ^ Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.
113. ^ a b Chang Y, Wang SJ. Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by resveratrol. Neurochem Int. (2009)
114. ^ a b c Gao ZB, Chen XQ, Hu GY. Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Res. (2006)
115. ^ Li M, et al. Resveratrol inhibits neuronal discharges in rat hippocampal CA1 area. Sheng Li Xue Bao. (2005)
116. ^ Gozlan H, Ben-Ari Y. NMDA receptor redox sites: are they targets for selective neuronal protection. Trends Pharmacol Sci. (1995)
117. ^ Abele R, et al. Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors. J Biol Chem. (1998)
118. ^ Zhang LP, et al. Effect of resveratrol on L-type calcium current in rat ventricular myocytes. Acta Pharmacol Sin. (2006)
119. ^ Moldzio R, et al. Protective effects of resveratrol on glutamate-induced damages in murine brain cultures. J Neural Transm. (2013)
120. ^ Lee JG, et al. Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol. (2012)
121. ^ Saleh MC, Connell BJ, Saleh TM. Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors. Neuroscience. (2010)
122. ^ Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. (1988)
123. ^ Lin CH, Chen PS, Gean PW. Glutamate preconditioning prevents neuronal death induced by combined oxygen-glucose deprivation in cultured cortical neurons. Eur J Pharmacol. (2008)
124. ^ Wang Q, et al. Resveratrol protects against neurotoxicity induced by kainic acid. Neurochem Res. (2004)
125. ^ Gupta YK, Briyal S, Chaudhary G. Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats. Pharmacol Biochem Behav. (2002)
126. ^ Shetty AK. Promise of resveratrol for easing status epilepticus and epilepsy. Pharmacol Ther. (2011)
127. ^ Wu Z, et al. Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochem Res. (2009)
128. ^ Friedman LK, et al. Lack of resveratrol neuroprotection in developing rats treated with kainic acid. Neuroscience. (2013)
129. ^ Friedman LK, et al. Developmental regulation of glutamate and GABA(A) receptor gene expression in rat hippocampus following kainate-induced status epilepticus. Dev Neurosci. (1997)
130. ^ Shen CH, et al. Intrathecal etanercept partially restores morphine’s antinociception in morphine-tolerant rats via attenuation of the glutamatergic transmission. Anesth Analg. (2011)
131. ^ Shimoyama N, et al. An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance. J Pharmacol Exp Ther. (2005)
132. ^ a b Tsai RY, et al. Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats. Anesth Analg. (2012)
133. ^ Cousins SL, Stephenson FA. Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. J Biol Chem. (2012)
134. ^ Magistretti PJ. Neuron-glia metabolic coupling and plasticity. J Exp Biol. (2006)
135. ^ Araque A. Astrocytes process synaptic information. Neuron Glia Biol. (2008)
136. ^ Araque A, Carmignoto G, Haydon PG. Dynamic signaling between astrocytes and neurons. Annu Rev Physiol. (2001)
137. ^ Araque A, et al. Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci. (1999)
138. ^ Hertz L. Glutamate, a neurotransmitter–and so much more. A synopsis of Wierzba III. Neurochem Int. (2006)
139. ^ Matés JM, et al. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol. (2002)
140. ^ McKenna MC. The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain. J Neurosci Res. (2007)
141. ^ Quincozes-Santos A, Gottfried C. Resveratrol modulates astroglial functions: neuroprotective hypothesis. Ann N Y Acad Sci. (2011)
142. ^ a b dos Santos AQ, et al. Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch Biochem Biophys. (2006)
143. ^ de Almeida LM, et al. Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures. Cell Mol Neurobiol. (2007)
144. ^ a b Bobermin LD, et al. Resveratrol prevents ammonia toxicity in astroglial cells. PLoS One. (2012)
145. ^ Felipo V, Butterworth RF. Neurobiology of ammonia. Prog Neurobiol. (2002)
146. ^ Leite MC, et al. Ammonia-induced alteration in S100B secretion in astrocytes is not reverted by creatine addition. Brain Res Bull. (2006)
147. ^ Lemberg A, Fernández MA. Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress. Ann Hepatol. (2009)
148. ^ a b Kwon KJ, et al. Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways. J Clin Neurol. (2010)
149. ^ a b c Kwon KJ, et al. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res. (2011)
150. ^ Porquet D, et al. Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8. Age (Dordr). (2012)
151. ^ a b Kao CL, et al. Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation. J Atheroscler Thromb. (2010)
152. ^ Zou J, et al. Effects of resveratrol on oxidative modification of human low density lipoprotein. Chin Med J (Engl). (2000)
153. ^ Zou JG, et al. Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein. Biochem Mol Biol Int. (1999)
154. ^ a b c Wallerath T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. (2002)
155. ^ Kleinert H, et al. Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension. (1998)
156. ^ Thum T, et al. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes. (2007)
157. ^ a b Li H, Förstermann U. Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des. (2009)
158. ^ Förstermann U, Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation. (2006)
159. ^ Li H, et al. Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol. (2006)
160. ^ Spanier G, et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol. (2009)
161. ^ Xia N, et al. Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther. (2010)
162. ^ Leonard SS, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. (2003)
163. ^ Orallo F, et al. The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol. (2002)
164. ^ a b Resveratrol Increases Nitric Oxide Synthase, Induces Accumulation of p53 and p21WAF1/CIP1, and Suppresses Cultured Bovine Pulmonary Artery EndothelialCell Proliferation by Perturbing Progression through S and G2.
165. ^ Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta.
166. ^ Rush JW, Denniss SG, Graham DA. Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity. Can J Appl Physiol. (2005)
167. ^ a b c d Rush JW, et al. Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp Biol Med (Maywood). (2007)
168. ^ a b Mizutani K, et al. Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). (2000)
169. ^ Wang Z, et al. Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts. Biochem Biophys Res Commun. (2006)
170. ^ Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide.
171. ^ Hsieh TC, et al. Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53. Biochem Biophys Res Commun. (2005)
172. ^ Wang Z, et al. Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography. Biochem Biophys Res Commun. (2004)
173. ^ Buryanovskyy L, et al. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry. (2004)
174. ^ a b de Gaetano G, et al. Antithrombotic effect of polyphenols in experimental models: a mechanism of reduced vascular risk by moderate wine consumption. Ann N Y Acad Sci. (2002)
175. ^ a b c d e f g h Timmers S, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. (2011)
176. ^ a b Brasnyó P, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. (2011)
177. ^ Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance.
178. ^ Ku CR, et al. Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase. Endocr J. (2012)
179. ^ Zhang J, et al. The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet. Diabetes Res Clin Pract. (2012)
180. ^ a b Minakawa M, et al. Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells. J Clin Biochem Nutr. (2011)
181. ^ Marchal J, et al. Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus. PLoS One. (2012)
182. ^ Burgess TA, et al. Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle. Arch Surg. (2011)
183. ^ Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ.
184. ^ Umek RM, Friedman AD, McKnight SL. CCAAT-enhancer binding protein: a component of a differentiation switch. Science. (1991)
185. ^ Rayalam S, et al. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother Res. (2008)
186. ^ a b c Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes.
187. ^ Szkudelska K, Nogowski L, Szkudelski T. Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes. J Steroid Biochem Mol Biol. (2009)
188. ^ Baile CA, et al. Effect of resveratrol on fat mobilization. Ann N Y Acad Sci. (2011)
189. ^ a b Fischer-Posovszky P, et al. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. (2010)
190. ^ SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes.
191. ^ Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
192. ^ AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol.
193. ^ a b c Dolinsky VW, et al. Improvements in Skeletal Muscle Strength and Cardiac Function Induced by Resveratrol Contribute to Enhanced Exercise Performance in Rats. J Physiol. (2012)
194. ^ a b Tomasello B, et al. Double-Face Activity of Resveratrol in Voluntary Runners: Assessment of DNA Damage by Comet Assay. J Med Food. (2012)
195. ^ de la Lastra CA, Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans. (2007)
196. ^ a b Liu M, Liu F. Resveratrol inhibits mTOR signaling by targeting DEPTOR. Commun Integr Biol. (2011)
197. ^ Liu M, et al. Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem. (2010)
198. ^ Rajapakse AG, et al. Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One. (2011)
199. ^ Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One. (2010)
200. ^ Schreiner CE, et al. Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner. Cardiovasc Res. (2011)
201. ^ Haider UG, et al. Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells. Mol Pharmacol. (2002)
202. ^ Drummond MJ, et al. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol. (2009)
203. ^ Jackson JR, Ryan MJ, Alway SE. Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. J Gerontol A Biol Sci Med Sci. (2011)
204. ^ Momken I, et al. Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat. FASEB J. (2011)
205. ^ Marzetti E, et al. Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty – a mini-review. Gerontology. (2012)
206. ^ Jian B, et al. Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1. Mol Med. (2012)
207. ^ a b Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men.
208. ^ Smoliga JM, Blanchard OL. Recent data do not provide evidence that resveratrol causes ‘mainly negative’ or ‘adverse’ effects on exercise training in humans. J Physiol. (2013)
209. ^ Gliemann L, et al. Reply from Lasse Gliemann, Jakob Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten. J Physiol. (2013)
210. ^ Continued Postnatal Administration of Resveratrol Prevents Diet-Induced Metabolic Syndrome in Rat Offspring Born Growth Restricted.
211. ^ a b Lagouge M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. (2006)
212. ^ a b Scribbans TD1, et al. Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. (2014)
213. ^ Gomez-Cabrera MC1, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr. (2008)
214. ^ Paulsen G1, et al. Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. J Physiol. (2014)
215. ^ Bäckesjö CM, et al. Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. Cells Tissues Organs. (2009)
216. ^ Resveratrol Stimulates the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells.
217. ^ Preventing bone loss & weight gain with combinations of Vitamin D & phytochemicals.
218. ^ Morita Y, et al. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary. Reprod Biol Endocrinol. (2012)
219. ^ Chen YC, et al. Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells. J Endocrinol. (2007)
220. ^ a b c Wang Y, et al. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci. (2006)
221. ^ a b Wang Y, Leung LK. Pharmacological concentration of resveratrol suppresses aromatase in JEG-3 cells. Toxicol Lett. (2007)
222. ^ Canistro D, et al. Alteration of xenobiotic metabolizing enzymes by resveratrol in liver and lung of CD1 mice. Food Chem Toxicol. (2009)
223. ^ a b Delmas D, et al. Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines. Oncol Rep. (2000)
224. ^ Sun ZJ, et al. Anti-hepatoma activity of resveratrol in vitro. World J Gastroenterol. (2002)
225. ^ Resveratrol Decreases Noise-Induced Cyclooxygenase-2 Expression in the Rat Cochlea.
226. ^ a b Leone S, et al. Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction. Cancer Lett. (2010)
227. ^ De Salvia R, et al. Resveratrol affects in a different way primary versus fixed DNA damage induced by H(2)O(2) in mammalian cells in vitro. Toxicol Lett. (2002)
228. ^ Fukuhara K, Miyata N. Resveratrol as a new type of DNA-cleaving agent. Bioorg Med Chem Lett. (1998)
229. ^ Transient Transfection of a Wild-Type p53 Gene Triggers Resveratrol-Induced Apoptosis in Cancer Cells.
230. ^ a b Delmas D, et al. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem. (2003)
231. ^ Pervaiz S. Resveratrol–from the bottle to the bedside. Leuk Lymphoma. (2001)
232. ^ Wenzel E, et al. Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol Nutr Food Res. (2005)
233. ^ a b Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention.
234. ^ Gao X, et al. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J Nutr. (2002)
235. ^ Oncogenic Activation of NF-κB.
236. ^ Kucharczak J, et al. To be, or not to be: NF-kappaB is the answer–role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene. (2003)
237. ^ a b Csaki C, Mobasheri A, Shakibaei M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. (2009)
238. ^ Benitez DA, et al. Regulation of cell survival by resveratrol involves inhibition of NF kappa B-regulated gene expression in prostate cancer cells. Prostate. (2009)
239. ^ Park ES, et al. Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Vascul Pharmacol. (2010)
240. ^ Bai Y, et al. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. (2010)
241. ^ Parekh P, et al. Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. Exp Toxicol Pathol. (2011)
242. ^ Hope C, et al. Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. Mol Nutr Food Res. (2008)
243. ^ Bishayee A, Dhir N. Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis. Chem Biol Interact. (2009)
244. ^ Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.
245. ^ Wang Y, Ye L, Leung LK. A positive feedback pathway of estrogen biosynthesis in breast cancer cells is contained by resveratrol. Toxicology. (2008)
246. ^ a b c Resveratrol Potentiates Genistein’s Antiadipogenic and Proapoptotic Effects in 3T3-L1 Adipocytes.
247. ^ Kleinedler JJ, et al. Synergistic effect of resveratrol and quercetin released from drug-eluting polymer coatings for endovascular devices. J Biomed Mater Res B Appl Biomater. (2011)
248. ^ Yang JY, et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. (2008)
249. ^ Park HJ, et al. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food. (2008)
250. ^ Rayalam S, Della-Fera MA, Baile CA. Synergism between resveratrol and other phytochemicals: implications for obesity and osteoporosis. Mol Nutr Food Res. (2011)
251. ^ a b Bruckbauer A, Zemel MB. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutr Metab (Lond). (2011)
252. ^ Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). (2012)
253. ^ Raj MH, et al. Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells. Gynecol Oncol. (2008)
254. ^ Trusov NV, et al. Effects of combined treatment with resveratrol and indole-3-carbinol. Bull Exp Biol Med. (2010)
255. ^ Malhotra A, Nair P, Dhawan DK. Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. Eur J Cancer Prev. (2011)
256. ^ Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Lett. (1990)
257. ^ Heerdt AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci. (1995)
258. ^ Olas B, Saluk-Juszczak J, Wachowicz B. D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets. Cell Biol Toxicol. (2008)
259. ^ a b Kowalczyk MC, et al. Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. Cancer Prev Res (Phila). (2010)
260. ^ a b c Vetvicka V, et al. Glucan and resveratrol complex–possible synergistic effects on immune system. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. (2007)
261. ^ Cristòfol R, et al. Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol. J Pineal Res. (2012)
262. ^ Lamont KT, et al. Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection. J Pineal Res. (2011)
263. ^ Kisková T, et al. A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur J Cancer Prev. (2012)
264. ^ Radhakrishnan S, et al. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Front Biosci (Elite Ed). (2011)
265. ^ Therapeutic potential of resveratrol: the in vivo evidence.
266. ^ Edwards JA, et al. Safety of resveratrol with examples for high purity, trans-resveratrol, resVida(®). Ann N Y Acad Sci. (2011)
267. ^ Johnson WD, et al. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem Toxicol. (2011)
268. ^ Patel KR, et al. Clinical trials of resveratrol. Ann N Y Acad Sci. (2011)
269. Magyar K, et al. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Microcirc. (2012)
270. Kennedy DO, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr. (2010)
271. Crandall JP, et al. Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance. J Gerontol A Biol Sci Med Sci. (2012)
272. Zhu W, et al. Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancer. Nutr Cancer. (2012)